Investigational research-grade biologic. ExoPearls™ are not approved therapeutic products and are not marketed as treatments for any condition. Supplied exclusively to licensed medical practitioners and verified research institutions under applicable local regulations. Practitioner assumes full clinical and regulatory responsibility.
Product Specifications

Full characterisation.

Every BEXO·NEURO vial is characterised per batch with NTA, TEM, and RNA-seq. Full documentation supplied with each order.

GradeInvestigational / Research Grade
AccessSpecialist access
Format2 × ExoPearl™ cryo-formed spheres / vial
Total Exosomes≥ 20 × 10⁹ per vial
ReconstitutionInstant dissolution in saline / bacteriostatic water
CharacterisationNTA · TEM · RNA-seq per batch
Surface MarkersCD9⁺ · CD63⁺ · CD81⁺
Endotoxin< 0.1 EU/mL post-reconstitution
SterilityUSP <71> confirmed per batch
ManufacturingGMP-certified source
StorageAmbient temperature · 12-month shelf life
AdministrationIV · Local injection
DocumentationCoA · Specialist protocol pack per batch
Key CargomiR-21 · miR-146a · BDNF · GDNF

Investigational Applications

Areas of research interest.

Peer-reviewed literature documents investigational interest in HMSC-derived exosomes across the following domains. BEXO·NEURO is characterised to confirm cargo relevance to each area.

01

Research & institutional use

For research institutions investigating HMSC-EV biology, signalling pathways, and cargo characterisation. Every BEXO·NEURO batch includes full RNA-seq data, NTA particle distribution, and TEM imaging - enabling reproducible downstream analysis without additional characterisation overhead.

RNA-seq characterisation per batch · NTA · TEM
02

IV rejuvenation & autoimmune modulation

Peer-reviewed literature documents investigational interest in HMSC-derived exosomes for M1→M2 macrophage transition, Th17 suppression, and Treg promotion. Evidence spans rheumatoid arthritis, SLE, and T1DM models. miR-146a - confirmed per batch via RNA-seq - is the key cargo mediator identified in this literature.

Frontiers Cell Dev Biol 2025 · Cell Death & Disease 2022 · J Inflammation 2024
03

Nerve pain & nerve repair

Peer-reviewed literature documents investigational interest in HMSC-derived exosomes for neuropathic pain and peripheral nerve injury, administered via local injection. miR-21 and BDNF signalling - confirmed per batch via RNA-seq - are the key cargo mediators identified in this literature.

Frontiers Cellular Neuroscience 2024

Cargo Profile

RNA-seq confirmed cargo.

BEXO·NEURO is enriched with neuroprotective, neurotrophic, and immunomodulatory cargo confirmed via RNA-seq per batch. The following cargo categories have been identified.

Neuroprotective · Neurotrophic
miR-21 miR-146a - BDNF GDNF
Immunomodulatory · Immunosuppressive
miR-146a → Treg promotion Th17 suppression - IL-10 TSG-6
Standard HMSC-EV Cargo
Tetraspanins (CD9, CD63, CD81) Growth factors Macrophage mediators ECM proteins

Enquire about BEXO·NEURO Request protocol pack