Backed by 28 Patents · Raw Biologic Ingredient

High-Purity hMSC ExoPearls

Flash-formed by dropping purified exosomes into liquid nitrogen, each ExoPearl™ preserves 10 billion hMSC exosomes in a precision-engineered frozen sphere. Room-temperature stable. No cold chain required. Supplied as purified raw material.

2 SpheresPer vial
10B+Exosomes per sphere
1 YearShelf life at room temp
GMPCertified facility
BEXO ExoPearls Vial
Solid Sphere Format
GMP & ISO Certified
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Third-Party Tested
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1 Year at Room Temp
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Full COA Provided
The Quality of BEXO®

BEXO partners exclusively with Asia's largest dedicated exosome manufacturer — a biotech leader holding 28 patents — to bring high-purity hMSC exosome raw material to buyers worldwide.

At BEXO®, our goal is to supply the best exosome products on the market. Our team of researchers constantly monitor the latest developments in exosome technology, ensuring you have access to the most up-to-date high-purity raw materials.

We are committed to maintaining exceptional safety measures, full transparency, and uncompromising quality in the development of our exosome products.

BEXO ExoPearls Vial
10B ExosomesPer sphere · hUC-MSC
99% PurityCell & virus-free
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Independent Third-Party Testing

Each batch of exosomes undergoes comprehensive virology testing by an independent laboratory. This process confirms the absence of viral contaminants and reinforces confidence in both the safety and integrity of our products.

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cGMP-Compliant Manufacturing

Our exosome products are produced in ISO-5 classified cleanroom environments within facilities that follow Current Good Manufacturing Practices (cGMP). This ensures consistent production quality and adherence to stringent industry standards.

Purification Process

Each vial undergoes advanced exosome purification technology, combining tangential flow filtration, composite and ion exchange chromatography, and ultrafiltration — delivering 99% purity and concentrations up to 1 μg/μL.

All products are cell and virus-free, verified through comprehensive independent laboratory testing and batch-level documentation.

Our exosomes are pure for flexible incorporation across a wide range of formulation, research, and manufacturing applications.

◉ 99% Purity Verified
Who Buys from BEXO

BEXO supplies purified hMSC exosome raw material to a broad range of buyers. Our documentation and specifications are designed to support your downstream requirements.

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Cosmetic & Skincare Formulators

Incorporating exosome raw material into proprietary formulations and finished products.

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Contract Manufacturers

Sourcing characterized, documented exosome ingredient for production-scale manufacturing.

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Distributors & Resellers

Building supply chains with fully documented, shelf-stable exosome raw material.

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Research Institutions

Procuring well-characterized hMSC exosomes for in vitro, in vivo, or mechanism-of-action studies.

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Individual Buyers

Purchasing exosome raw material for personal use or evaluation. No minimum order required.

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White Label / OEM Partners

Launching branded exosome products using BEXO raw material with custom packaging and documentation.

Why ExoPearls™ Change Everything

Traditional exosomes ship as fragile liquids requiring −80°C storage. ExoPearls™ are flash-formed in liquid nitrogen — locking in bioactivity at room temperature.

Traditional liquid exosomes degrade quickly and demand expensive cold chain logistics. BEXO's proprietary sphere technology solves both problems.

Traditional Exosomes
  • Liquid format — fragile & inconsistent
  • Requires −80°C cold chain shipping
  • Hours to days at room temperature
  • 1 year shelf life at −80°C
  • Thaw/freeze cycles degrade potency
  • Difficult to standardize concentration
VS
BEXO ExoPearls™
  • Solid sphere — stable & precise
  • Room temperature stable for 1 year
  • 3-year shelf life at −20°C
  • Ship anywhere — no cold chain needed
  • No degradation from handling
  • Exact 10B exosomes per sphere
0 Exosome Patents Held
0B Exosomes per Vial
0%+ Purity Verified
0 Year Shelf Life at Room Temp
ExoPearls™ Product Line

Each vial contains 2 ExoPearls™ — flash-formed in liquid nitrogen — with 10 billion hMSC exosomes per pearl. Room temperature stable. No cold chain required.

Starter

BEXO Single Vial

1 Vial — 20 Billion Exosomes

  • 2 × ExoPearls™ per vial
  • 20 billion exosomes total
  • hUC-MSC derived
  • 1 year shelf life at room temp
  • Full COA included
$780 per vial
Ideal for evaluation or small-scale formulation testing
Order Now
Formulation Pack

BEXO 5-Pack

5 Vials — 100 Billion Exosomes

  • 5 vials × 20 billion each
  • 100 billion exosomes total
  • hUC-MSC derived
  • 1 year room temp / 3 years at −20°C
  • Full COA + batch traceability
$3,400 $680/vial Save $500 vs singles
For formulators requiring ongoing supply at reduced cost
Order Now
Wholesale

Volume Orders

200+ Vials — Wholesale Pricing

  • 200+ vials per order
  • Dedicated account manager
  • Priority fulfillment
  • Custom packaging available
  • Full COA + batch traceability
$180 per vial · 200+ units Save 77% vs single vial
Need larger volumes? Contact us for further reductions
Get Wholesale Pricing →
White Label

Build Your Own Brand

1,000+ Vials — Private Label Program

  • Your brand, our product
  • Custom packaging & labeling
  • Exclusive territory agreements
  • Full regulatory support
  • Full COA under your brand
Custom tailored to your volume & market
Launch your own exosome brand with the world's best product inside
Discuss White Label →
💡 The more you order, the more you save
1 vial $780/vial
5 vials $680/vial
10 vials $595/vial
200+ vials $180/vial
1,000+ Contact us
Molecular Profile & Characterization
📄 Published Characterization Data🔬 28-Patent Manufacturer🏭 GMP & ISO Certified

hMSC-derived exosomes are nano-sized extracellular vesicles (30–150nm) characterized by their protein, lipid, and microRNA cargo profiles. Below are the key analytical parameters documented for BEXO raw material.

01

Particle Size Distribution

Nanoparticle Tracking Analysis (NTA) confirms a mean particle diameter of 118nm with a mode of 104nm, consistent with exosome-class vesicles (30–150nm range).

02

Surface Marker Expression

Positive for canonical exosome tetraspanins CD9, CD63, and CD81. Negative for cellular contaminant markers, confirming high-purity vesicle isolation.

03

Protein Cargo Profiling

BCA assay-verified protein concentration of 1.8 mg/mL. Proteomic analysis identifies growth factor, cytokine, and extracellular matrix-associated proteins in the vesicle cargo.

04

Lipid Membrane Composition

Characteristic exosome lipid bilayer enriched in sphingomyelin, cholesterol, and phosphatidylserine, contributing to vesicle stability and membrane integrity.

Raw Material Specifications

Typical batch characterization values

Particle Count (NTA)2.1 x 1010 / vial
Mean Particle Size118 nm ± 22 nm
Mode Particle Size104 nm
Protein Concentration1.8 mg/mL
Purity≥99%
Endotoxin<0.5 EU/mL
SterilityPass (USP <71>)
MycoplasmaNegative

Values represent typical batch data. Actual specifications documented in the Certificate of Analysis provided with each order.

What Sets Us Apart

Not all exosome products are created equal. Here's what to look for — and what we deliver.

What Matters
Industry Avg.
BEXO
Manufacturer Patents
Few or none
28 patents ✓
Exosomes per Vial
Varies / unverified
20B verified ✓
Cold Chain Required
Usually yes
No — room temp stable ✓
Shelf Life
3–6 months (at −80°C)
1 year room temp ✓
Purity
Often unspecified
99%+ third-party verified ✓
COA Transparency
Basic or absent
Full characterization data ✓
Technical Documentation
Basic or absent
Full characterization data & specs included ✓
Built for Wholesale Partners

Everything formulators, manufacturers, and distributors need to source exosome raw material at scale.

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GMP Manufacturing

ISO-certified cleanroom facilities with rigorous quality control at every stage.

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Full Documentation

COA, sterility reports, endotoxin testing, and characterization data with every batch.

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No Cold Chain

1 year at room temp, 3 years at −20°C — slashing logistics costs and simplifying storage.

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Scalable Supply

From pilot orders to recurring wholesale contracts, production scales with your growth.

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R&D Support

Custom specifications, formulation support, and regulatory documentation from our science team.

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White Label

Private label programs for brands and distributors building their own product line.

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Key Markets

Serving Southeast Asia, Australia, Africa, and Eastern Europe with localized logistics support.

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Dedicated Manager

Every partner gets a dedicated contact for ordering, support, and planning.

Available in the concentrations and volumes your formulation requires

20B
Exosomes per vial (2 ExoPearls x 10B each) — our standard unit of supply
99%+
Verified purity via multi-step chromatographic purification and independent third-party testing
Custom
Concentrations, volumes, and packaging available for OEM and production-scale orders on request

BEXO supplies exosome raw material in standardized and custom configurations. Contact us for specifications tailored to your formulation or production requirements.

From Inquiry to Delivery
01

Inquiry

Tell us about your application, volume requirements, and desired specifications.

02

Documentation Review

We send you full COA, characterization data, and product specs before you order.

03

Contract & Production

Lock in pricing and volume. Production begins in our GMP facility.

04

Delivery & Support

Room-temp delivery worldwide with ongoing technical support.

Estimate Your Order

Calculate pricing based on the number of vials you need. Volume discounts apply automatically.

110200
Total Vials 10
Total Exosomes 200B
Estimated Cost $5,950
Cost per Vial $595
💡 10-pack pricing applied at $595/vial. Order 200+ to unlock wholesale at $180/vial
Get a Quote for This Volume →
Your Direct Line to the
World's Best Exosomes

"We saw the gap: the world's most advanced exosome manufacturer, and no reliable way for buyers worldwide to access their material. We built the supply bridge."

BEXO was founded to solve a supply problem. Asia's leading exosome biotech — holder of 28 patents — produces the highest-quality hMSC exosomes available. But buyers outside their network had no way to access the raw material. Our team, which includes a PhD nuclear biologist, handles sourcing, quality verification, logistics, and documentation so you can focus on your formulation.

🔬 PhD-led science team
🤝 Partner, not vendor
📄 Full transparency on sourcing
🌏 Registered in Hong Kong
Become a BEXO Founding Partner
🚀 Early Adopter Advantage

Why join now?

  • ✦ Founding partner pricing locked in
  • ✦ Priority access to new products
  • ✦ Direct line to our science team
  • ✦ Shape the product roadmap with us
  • ✦ Exclusive territory agreements available
🔬 Backed by Science

What you're getting

  • ✦ Product from the world's largest exosome manufacturer
  • ✦ 28 patents backing the technology
  • ✦ Full COA and third-party testing
  • ✦ No cold chain — simple logistics
  • ✦ hMSC universal exosomes — versatile raw material

🌍 We're building the supply bridge between the world's most advanced exosome manufacturer and buyers worldwide. Be part of it from the beginning.

The Science Behind hMSC Exosomes

hMSC-derived exosomes are the subject of a growing body of peer-reviewed research. Below are published studies characterizing the molecular composition, vesicle biology, and mechanism-of-action of hMSC exosomes.

Vesicle Biology

Bioengineered MSC-Derived Exosomes in Skin Wound Repair and Regeneration

Frontiers in Cell and Developmental Biology · 2023

Comprehensive review showing hUC-MSC exosomes promote fibroblast proliferation and migration, enhance collagen synthesis, and inhibit the TGF-β1/Smad2/3 signaling pathway in wound healing models.

View on PubMed →
Cargo Characterization

Exosomes in Skin Photoaging: Biological Functions and Therapeutic Opportunity

Cell Communication and Signaling · 2024

Stem cell-derived exosomes restore skin function via decreased MMP expression, increased collagen and elastin production, and modulation of intracellular signaling pathways against UV-induced photoaging.

View on PubMed →
Mechanism of Action

Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing

Stem Cell Research & Therapy · 2023

Comprehensive review of how MSC-derived exosomes transfer bioactive cargo (miRNAs, proteins) to target cells, modulating inflammation, promoting angiogenesis, and accelerating tissue repair.

View on PubMed →
Cell Signaling

Exosomes from Human Umbilical Cord MSCs Promote the Growth of Hair Dermal Papilla Cells

PLOS ONE · 2025

UC-MSC exosomes enhanced dermal papilla cell proliferation via PI3K/Akt pathway activation, increased β-catenin and cyclin D1 expression — outperforming minoxidil in promoting cell growth.

View on PubMed →
In Vivo Characterization

MSC-Derived Exosomes Attenuate Cell Death and Enhance Cutaneous Wound Healing

Stem Cell Research & Therapy · 2020

hucMSC exosomes increased keratinocyte proliferation and migration in a dose-dependent manner, suppressed apoptosis via AIF/PARP-1 pathways, and enhanced dermal angiogenesis in vivo wound models.

View on PubMed →
Topical Formulation Study

Topical Application of hucMSC Exosomes with Sponge Spicules for Treatment of Photoaging

International Journal of Nanomedicine · 2020

Combined hucMSC exosome application showed significant anti-photoaging effects in mice, reducing microwrinkles, alleviating histopathological changes, and promoting extracellular matrix expression.

View on PubMed →
Immunomodulation Pathway

hUC-MSC Exosomes Attenuate Neuropathic Pain by Inhibiting TLR2/MyD88/NF-κB in Spinal Microglia

International Journal of Nanomedicine · 2022

hUC-MSC exosomes suppressed microglial activation and inhibited TLR2/MyD88/NF-κB signaling in both in vitro and chronic constriction injury rat models, demonstrating significant analgesic effects on neuropathic pain.

View on PubMed →
Biodistribution

UCMSC Exosomes as Cell-Free Therapy for Nerve Injury–Induced Pain in Rats

PAIN (IASP Journal) · 2019

Single intrathecal injection of UCMSC exosomes reversed nerve ligation–induced mechanical and thermal hypersensitivities. Exosomes homed to spinal dorsal horn, DRG, and peripheral axons, suppressing neuroinflammatory markers.

View on PubMed →
Tissue Engineering

hUC-MSC Exosome-Loaded Gelfoam Improves Locomotor Dysfunction and Neuropathic Pain After SCI

Stem Cell Research & Therapy · 2024

hUC-MSC exosomes promoted nerve regeneration, remyelination, and synapse formation while reducing pain-associated proteins (BDNF, TRPV1, Cav3.2) in a spinal cord injury rat model.

View on PubMed →
Isolation & Cargo Review

MSC-Derived Exosomes-Based Therapy for Peripheral Nerve Injury: A Novel Strategy

BioMed Research International · 2019

Comprehensive review showing MSC exosomes shuttle bioactive miRNAs, proteins and lipids that promote Schwann cell proliferation, axonal regeneration, and remyelination — offering a cell-free alternative for peripheral nerve repair.

View on PubMed →
Paracrine Signaling

MSC-Derived Exosomes as a Promising Cell-Free Therapy for Knee Osteoarthritis

Frontiers in Bioengineering and Biotechnology · 2024

MSC exosomes reduced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), promoted cartilage regeneration, and enhanced M2 macrophage polarization in OA models — emerging as a cell-free alternative to joint replacement.

View on PubMed →

These are published studies on hMSC-derived exosomes provided for informational purposes. BEXO does not make therapeutic, diagnostic, or efficacy claims. The intended use of raw material purchased from BEXO is determined solely by the buyer.

Full COA with
Every Order

Every BEXO shipment includes a comprehensive Certificate of Analysis. We don't hide behind vague specifications — we show you exactly what's in the vial.

Particle count & size distribution (NTA verified)
Protein concentration (BCA assay)
Surface marker characterization (CD9, CD63, CD81)
Sterility & endotoxin testing
Mycoplasma testing — negative confirmed
Purity: ≥99%
Batch number & production date
Storage & handling instructions
Request a Sample COA →
BEXO — Certificate of Analysis ExoPearls™ hMSC Exosomes
ProductBEXO ExoPearls™ hUC-MSC
Batch No.BXS-2026-0147
Manufacture Date2026-01-15
Expiry Date2027-01-15
Particle Count (NTA)2.1 × 10¹⁰ / vial
Mean Particle Size118 nm ± 22 nm
Mode Particle Size104 nm
Protein Conc.1.8 mg/mL
CD9Positive ✓
CD63Positive ✓
CD81Positive ✓
SterilityPass ✓
Endotoxin<0.5 EU/mL ✓
MycoplasmaNegative ✓
Purity≥99% ✓
Science-Led. Quality-Focused.

BEXO is led by a team that combines scientific expertise in exosome isolation, characterization, and supply chain management.

👨‍🔬

Dr. [Name]

Chief Science Officer

PhD Nuclear Biology

Leads product quality verification, third-party testing protocols, and scientific due diligence on all BEXO products. Ensures every batch meets high-purity raw material specifications.

👤

[Founder Name]

Founder & CEO

BEXO, Hong Kong

Identified the supply gap between Asia's leading exosome manufacturer and global buyers. Built BEXO to be the trusted supply bridge — with transparency as the foundation.

Our team works directly with a manufacturer holding 28 exosome patents — the largest dedicated exosome biotech in Asia.

Understanding the
Regulatory Landscape

Exosome-derived raw materials exist in an evolving regulatory environment. BEXO is committed to transparency about classification and to providing documentation that supports our buyers' compliance needs.

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GMP Manufacturing

All products manufactured in ISO-certified, GMP-compliant cleanroom facilities with full process documentation.

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Full Traceability

Every batch is traceable from raw material sourcing through manufacturing, testing, packaging, and delivery.

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Third-Party Testing

Independent laboratory verification of particle count, sterility, endotoxin levels, and purity for every production batch.

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Market-Specific Compliance

We work with regulatory consultants in Southeast Asia, Australia, Africa, and Eastern Europe to ensure our documentation meets local requirements.

Important note: hMSC-derived exosomes are classified differently across jurisdictions. BEXO supplies exosome raw material and does not make therapeutic, diagnostic, or cosmetic efficacy claims. It is the sole responsibility of the purchaser to ensure that their intended use and any claims made about finished products comply with applicable regulations in their jurisdiction.

Frequently Asked Questions

Exosomes are nano-sized extracellular vesicles (30–150nm) naturally secreted by human mesenchymal stem/stromal cells (hMSCs). They are characterized by their cargo of proteins, lipids, and microRNAs, and identified by surface marker expression (CD9, CD63, CD81). BEXO supplies hMSC exosomes as a purified raw biologic ingredient.

Human umbilical cord-derived MSC (hUC-MSC) exosomes are widely studied in published literature and are considered a versatile source due to broad biological compatibility. Our manufacturer selected this tissue origin after comparative evaluation across multiple MSC sources based on yield, consistency, and scalability.

Each vial contains 2 ExoPearls with 10 billion exosomes per pearl (20 billion total per vial). We offer single vials, 5-packs (100B), 10-packs (200B), wholesale quantities (200+ vials), and custom OEM configurations. Contact us for specifications tailored to your formulation or production requirements.

ExoPearls™ are formed by dropping purified exosomes into liquid nitrogen, creating a stable frozen sphere that preserves material integrity at room temperature for 1 year — no cold chain required. For extended storage, they remain stable for up to 3 years at −20°C. This represents a significant handling advantage over traditional liquid exosome raw material, which typically requires −80°C storage and has a shelf life of just 3–6 months.

BEXO supplies hMSC-derived exosomes as raw biologic material. We do not classify or market our products as drugs, biologics, medical devices, or cosmetics. Regulatory classification of finished products incorporating exosome raw material is the responsibility of the buyer, and varies by jurisdiction. We provide full manufacturing documentation (COA, GMP certificates, batch traceability) to support our buyers' regulatory submissions.

Every order includes a comprehensive Certificate of Analysis (COA) with: particle count via NTA, mean and mode particle size, protein concentration, surface marker characterization (CD9, CD63, CD81), sterility testing, endotoxin testing, mycoplasma testing, purity verification, and batch traceability data. We also provide storage and handling instructions.

BEXO partners exclusively with Asia's largest dedicated exosome manufacturer — a biotech company holding 28 exosome-related patents. They operate GMP-certified, ISO-compliant cleanroom facilities. We do not disclose the manufacturer's name to protect our supply chain, but we provide full documentation and welcome third-party verification of our products.

There is no minimum order — you can start with a single vial ($780). Volume pricing is available at 5+ vials ($680/vial), 10+ vials ($595/vial), and 200+ vials ($180/vial). White label programs are available for orders of 1,000+ vials. Contact us for custom volume pricing on larger orders.

BEXO primarily serves Southeast Asia, Australia, Africa, and Eastern Europe. We ship worldwide and work with regulatory consultants to ensure our documentation meets the requirements of each market. Room-temperature stability means no cold chain logistics are needed, making global shipping simple and cost-effective.

If independent third-party lab testing shows our product doesn't meet the specifications stated on the COA, we will issue a full refund. Simply submit the lab report and we'll make it right. We stand behind the quality of every batch because our reputation depends on it.

Ready to Be Extraordinary?

Source high-purity hMSC ExoPearls™ raw material with full documentation. Our team responds within 24 hours.

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No Minimum Commitment Start with a single vial. Evaluate the material. Scale when you're ready.
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Full COA Before You Buy We'll send you complete documentation upfront — verify our claims yourself
🛡️ Quality Guarantee — If independent third-party lab testing shows our product doesn't meet the specifications on the COA, we'll issue a full refund. Submit your lab report and we'll make it right.

No minimum order. Ships worldwide. Full documentation provided with every order.